G28S (p.Gly28Ser) variant of MAP2K2 (P36507)
G28S (p.Gly28Ser) in MAP2K2 (P36507) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
G28S (p.Gly28Ser) variant details
- p.Gly28Ser
- Ensembl rs2145089750
- Missense
- Variant Prioritization Score for Impact Estimate 0.416
- REVEL 0.27
- AlphaMissense 0.11
- MetaLR 0.14
- MetaSVM -0.86
- CADD 21.90
- PolyPhen-2 0.24
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available