E20D (p.Glu20Asp) variant of MAP2K2 (P36507)
E20D (p.Glu20Asp) in MAP2K2 (P36507) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
E20D (p.Glu20Asp) variant details
- p.Glu20Asp
- NCI-TCGA TCGA novel
- Ensembl rs2145089821
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.327
- REVEL 0.25
- CADD 21.50
- PolyPhen-2 0.00
- SIFT 0.34
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available