A32E (p.Ala32Glu) variant of MAP2K2 (P36507)
A32E (p.Ala32Glu) in MAP2K2 (P36507) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
A32E (p.Ala32Glu) variant details
- p.Ala32Glu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.512
- REVEL 0.34
- CADD 24.00
- PolyPhen-2 0.63
- SIFT 0.22
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available