R76W (p.Arg76Trp) variant of MAGED2 (Melanoma-associated antigen D2)
R76W (p.Arg76Trp) in MAGED2 (Melanoma-associated antigen D2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
R76W (p.Arg76Trp) variant details
- p.Arg76Trp
- rs767820484
- NCI-TCGA Cosmic COSV9951
- cosmic curated COSV99514
- TOPMed rs767820484
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.165
- REVEL 0.05
- CADD 21.80
- PolyPhen-2 0.01
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available