L31S (p.Leu31Ser) variant of MAGED2 (Melanoma-associated antigen D2)
L31S (p.Leu31Ser) in MAGED2 (Melanoma-associated antigen D2) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes structural context.
L31S (p.Leu31Ser) variant details
- p.Leu31Ser
- rs147495006
- ClinVar RCV004585732
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.315
- AlphaMissense 0.16
- MetaLR 0.17
- MetaSVM -0.96
- PolyPhen-2 1.00
- SIFT 0.00
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available