D15G (p.Asp15Gly) variant of LYST (Lysosomal-trafficking regulator)
D15G (p.Asp15Gly) in LYST (Lysosomal-trafficking regulator) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data and structural context.
D15G (p.Asp15Gly) variant details
- p.Asp15Gly
- rs773170266
- NCI-TCGA Cosmic COSV6770
- ExAC rs773170266
- gnomAD rs773170266
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.684
- REVEL 0.71
- CADD 26.80
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available