W10L (p.Trp10Leu) variant of LRP5 (O75197)
W10L (p.Trp10Leu) in LRP5 (O75197) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, published literature, and structural context.
W10L (p.Trp10Leu) variant details
- p.Trp10Leu
- gnomAD 11-68312743-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.438
- REVEL 0.33
- CADD 4.44
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00017)
- Structural context available
- Literature evidence available