W10C (p.Trp10Cys) variant of LRP5 (O75197)
W10C (p.Trp10Cys) in LRP5 (O75197) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
W10C (p.Trp10Cys) variant details
- p.Trp10Cys
- gnomAD 11-68312744-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.241
- REVEL 0.18
- CADD 10.70
- PolyPhen-2 0.00
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- Literature evidence available