P9L (p.Pro9Leu) variant of LRP5 (O75197)
P9L (p.Pro9Leu) in LRP5 (O75197) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
P9L (p.Pro9Leu) variant details
- p.Pro9Leu
- TOPMed rs1174353023
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- REVEL 0.26
- CADD 13.90
- PolyPhen-2 0.73
- SIFT 0.60
- Most common in the African/African-American population (allele frequency 5.8e-05)
- Structural context available