P8S (p.Pro8Ser) variant of LRP5 (O75197)
P8S (p.Pro8Ser) in LRP5 (O75197) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, published literature, and structural context.
P8S (p.Pro8Ser) variant details
- p.Pro8Ser
- gnomAD 11-68312736-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.23
- REVEL 0.22
- CADD 9.36
- PolyPhen-2 0.00
- SIFT 0.24
- Most common in the Latino/Admixed American population (allele frequency 0.00018)
- Structural context available
- Literature evidence available