L22M (p.Leu22Met) variant of LRP5 (O75197)
L22M (p.Leu22Met) in LRP5 (O75197) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
L22M (p.Leu22Met) variant details
- p.Leu22Met
- gnomAD rs1474195508
- Missense
- Variant Prioritization Score for Impact Estimate 0.301
- REVEL 0.27
- CADD 17.10
- PolyPhen-2 0.67
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 7.3e-06)
- Structural context available