L18P (p.Leu18Pro) variant of LRP5 (O75197)
L18P (p.Leu18Pro) in LRP5 (O75197) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
L18P (p.Leu18Pro) variant details
- p.Leu18Pro
- gnomAD rs1445972969
- Missense
- Variant Prioritization Score for Impact Estimate 0.382
- REVEL 0.48
- CADD 22.00
- PolyPhen-2 0.77
- SIFT 0.21
- Most common in the REMAINING population (allele frequency 3.1e-05)
- Structural context available