R85C (p.Arg85Cys) variant of LRP4 (O75096)
R85C (p.Arg85Cys) in LRP4 (O75096) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.89 / 1. The record also includes population frequency data and structural context.
R85C (p.Arg85Cys) variant details
- p.Arg85Cys
- rs1219866663
- NCI-TCGA Cosmic COSV1010
- Ensembl rs1219866663
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.887
- AlphaMissense 0.90
- MetaLR 0.91
- MetaSVM 1.01
- PolyPhen-2 1.00
- SIFT 0.01
- MutPred 0.61
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available