V37M (p.Val37Met) variant of LHCGR (P22888)
V37M (p.Val37Met) in LHCGR (P22888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
V37M (p.Val37Met) variant details
- p.Val37Met
- NCI-TCGA Cosmic COSV5429
- TOPMed rs1670170905
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.212
- REVEL 0.18
- CADD 16.90
- PolyPhen-2 0.09
- SIFT 0.22
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.9e-06)
- Structural context available