R88K (p.Arg88Lys) variant of LHCGR (P22888)
R88K (p.Arg88Lys) in LHCGR (P22888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
R88K (p.Arg88Lys) variant details
- p.Arg88Lys
- NCI-TCGA Cosmic COSV5429
- cosmic curated COSV54297
- NCI-TCGA Cosmic COSV9968
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.201
- REVEL 0.11
- CADD 16.70
- PolyPhen-2 0.01
- SIFT 0.48
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available