P65S (p.Pro65Ser) variant of LHCGR (P22888)
P65S (p.Pro65Ser) in LHCGR (P22888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
P65S (p.Pro65Ser) variant details
- p.Pro65Ser
- cosmic curated COSV10459
- ExAC rs772574574
- TOPMed rs772574574
- gnomAD rs772574574
- Missense
- Variant Prioritization Score for Impact Estimate 0.75
- REVEL 0.74
- CADD 23.80
- PolyPhen-2 1.00
- SIFT 0.15
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available