P45H (p.Pro45His) variant of LHCGR (P22888)
P45H (p.Pro45His) in LHCGR (P22888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
P45H (p.Pro45His) variant details
- p.Pro45His
- TOPMed rs1670168989
- gnomAD rs1670168989
- Missense
- Variant Prioritization Score for Impact Estimate 0.322
- REVEL 0.26
- CADD 22.80
- PolyPhen-2 0.01
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available