L25P (p.Leu25Pro) variant of LHCGR (P22888)
L25P (p.Leu25Pro) in LHCGR (P22888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
L25P (p.Leu25Pro) variant details
- p.Leu25Pro
- 1000Genomes rs549032969
- TOPMed rs549032969
- Missense
- Variant Prioritization Score for Impact Estimate 0.475
- REVEL 0.46
- CADD 17.70
- PolyPhen-2 0.14
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 2.8e-06)
- Structural context available