K109T (p.Lys109Thr) variant of LHCGR (P22888)
K109T (p.Lys109Thr) in LHCGR (P22888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
K109T (p.Lys109Thr) variant details
- p.Lys109Thr
- NCI-TCGA Cosmic COSV5429
- cosmic curated COSV54292
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.611
- REVEL 0.70
- CADD 26.20
- PolyPhen-2 0.82
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available