I78M (p.Ile78Met) variant of LHCGR (P22888)
I78M (p.Ile78Met) in LHCGR (P22888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
I78M (p.Ile78Met) variant details
- p.Ile78Met
- ExAC rs753671958
- gnomAD rs753671958
- Missense
- Variant Prioritization Score for Impact Estimate 0.587
- REVEL 0.77
- CADD 23.70
- PolyPhen-2 1.00
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available