E87K (p.Glu87Lys) variant of LHCGR (P22888)
E87K (p.Glu87Lys) in LHCGR (P22888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
E87K (p.Glu87Lys) variant details
- p.Glu87Lys
- rs149019093
- NCI-TCGA Cosmic COSV5430
- cosmic curated COSV54303
- 1000Genomes rs149019093
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.513
- REVEL 0.48
- CADD 24.30
- PolyPhen-2 1.00
- SIFT 0.15
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:CEU population (allele frequency 0.0042)
- Structural context available