D95N (p.Asp95Asn) variant of LHCGR (P22888)
D95N (p.Asp95Asn) in LHCGR (P22888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
D95N (p.Asp95Asn) variant details
- p.Asp95Asn
- NCI-TCGA Cosmic COSV9968
- cosmic curated COSV99683
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.49
- REVEL 0.28
- CADD 24.20
- PolyPhen-2 0.70
- SIFT 0.34
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available