Y64F (p.Tyr64Phe) variant of LEPR (Leptin receptor)
Y64F (p.Tyr64Phe) in LEPR (Leptin receptor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
Y64F (p.Tyr64Phe) variant details
- p.Tyr64Phe
- NCI-TCGA Cosmic COSV6075
- cosmic curated COSV60759
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.105
- REVEL 0.09
- CADD 6.98
- PolyPhen-2 0.27
- SIFT 0.66
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available