Y64C (p.Tyr64Cys) variant of LEPR (Leptin receptor)
Y64C (p.Tyr64Cys) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
Y64C (p.Tyr64Cys) variant details
- p.Tyr64Cys
- gnomAD rs1445275733
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.16
- CADD 17.40
- PolyPhen-2 0.71
- SIFT 0.17
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available