Y46F (p.Tyr46Phe) variant of LEPR (Leptin receptor)
Y46F (p.Tyr46Phe) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data, published literature, and structural context.
Y46F (p.Tyr46Phe) variant details
- p.Tyr46Phe
- gnomAD 1-65570569-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.0594
- REVEL 0.05
- CADD 0.30
- PolyPhen-2 0.10
- SIFT 0.68
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available