T66P (p.Thr66Pro) variant of LEPR (Leptin receptor)
T66P (p.Thr66Pro) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
T66P (p.Thr66Pro) variant details
- p.Thr66Pro
- 1000Genomes rs561158528
- ExAC rs561158528
- gnomAD rs561158528
- Missense
- Variant Prioritization Score for Impact Estimate 0.276
- REVEL 0.07
- CADD 7.56
- PolyPhen-2 0.00
- SIFT 0.30
- Most common in the 1KG:IBS population (allele frequency 0.0048)
- Structural context available