T66A (p.Thr66Ala) variant of LEPR (Leptin receptor)
T66A (p.Thr66Ala) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.
T66A (p.Thr66Ala) variant details
- p.Thr66Ala
- gnomAD 1-65570628-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.08
- CADD 1.45
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available