S75R (p.Ser75Arg) variant of LEPR (Leptin receptor)
S75R (p.Ser75Arg) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
S75R (p.Ser75Arg) variant details
- p.Ser75Arg
- TOPMed rs1654089862
- gnomAD rs1654089862
- Missense
- Variant Prioritization Score for Impact Estimate 0.248
- REVEL 0.09
- CADD 18.00
- PolyPhen-2 0.02
- SIFT 0.14
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available