S58T (p.Ser58Thr) variant of LEPR (Leptin receptor)
S58T (p.Ser58Thr) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
S58T (p.Ser58Thr) variant details
- p.Ser58Thr
- ESP rs150657671
- TOPMed rs150657671
- gnomAD rs150657671
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.13
- CADD 22.80
- PolyPhen-2 0.94
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available