R32S (p.Arg32Ser) variant of LEPR (Leptin receptor)
R32S (p.Arg32Ser) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
R32S (p.Arg32Ser) variant details
- p.Arg32Ser
- ESP rs373650495
- ExAC rs373650495
- TOPMed rs373650495
- gnomAD rs373650495
- Missense
- Variant Prioritization Score for Impact Estimate 0.171
- REVEL 0.08
- CADD 21.00
- PolyPhen-2 0.01
- SIFT 0.50
- Most common in the African/African-American population (allele frequency 0.00019)
- Structural context available