P27A (p.Pro27Ala) variant of LEPR (Leptin receptor)
P27A (p.Pro27Ala) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
P27A (p.Pro27Ala) variant details
- p.Pro27Ala
- ExAC rs757574299
- TOPMed rs757574299
- gnomAD rs757574299
- Missense
- Variant Prioritization Score for Impact Estimate 0.273
- REVEL 0.13
- CADD 19.30
- PolyPhen-2 0.51
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available