N81S (p.Asn81Ser) variant of LEPR (Leptin receptor)
N81S (p.Asn81Ser) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
N81S (p.Asn81Ser) variant details
- p.Asn81Ser
- cosmic curated COSV60762
- TOPMed rs1654091044
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.12
- CADD 6.94
- PolyPhen-2 0.11
- SIFT 0.55
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available