L10F (p.Leu10Phe) variant of LEPR (Leptin receptor)
L10F (p.Leu10Phe) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L10F (p.Leu10Phe) variant details
- p.Leu10Phe
- TOPMed rs1390307326
- Missense
- Variant Prioritization Score for Impact Estimate 0.25
- REVEL 0.04
- CADD 13.80
- PolyPhen-2 0.00
- SIFT 0.35
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available