I16T (p.Ile16Thr) variant of LEPR (Leptin receptor)
I16T (p.Ile16Thr) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
I16T (p.Ile16Thr) variant details
- p.Ile16Thr
- ExAC rs766684961
- TOPMed rs766684961
- gnomAD rs766684961
- Missense
- Variant Prioritization Score for Impact Estimate 0.285
- REVEL 0.23
- CADD 22.90
- PolyPhen-2 0.12
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available