F6L (p.Phe6Leu) variant of LEPR (Leptin receptor)
F6L (p.Phe6Leu) in LEPR (Leptin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
F6L (p.Phe6Leu) variant details
- p.Phe6Leu
- cosmic curated COSV60751
- TOPMed rs1465011978
- gnomAD rs1465011978
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.02
- CADD 20.20
- PolyPhen-2 0.00
- SIFT 0.41
- Most common in the Ashkenazi Jewish population (allele frequency 0.00015)
- Structural context available