Y51F (p.Tyr51Phe) variant of LCK (Tyrosine-protein kinase Lck)
Y51F (p.Tyr51Phe) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Y51F (p.Tyr51Phe) variant details
- p.Tyr51Phe
- TOPMed rs1404547164
- gnomAD rs1404547164
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.11
- CADD 17.70
- PolyPhen-2 0.00
- SIFT 0.61
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0373