Y51C (p.Tyr51Cys) variant of LCK (Tyrosine-protein kinase Lck)
Y51C (p.Tyr51Cys) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Y51C (p.Tyr51Cys) variant details
- p.Tyr51Cys
- TOPMed rs1404547164
- gnomAD rs1404547164
- Missense
- Variant Prioritization Score for Impact Estimate 0.334
- REVEL 0.14
- CADD 22.60
- PolyPhen-2 0.44
- SIFT 0.12
- Most common in the East Asian population (allele frequency 5e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0373