Y25* (p.Tyr25Ter) variant of LCK (Tyrosine-protein kinase Lck)
Y25* (p.Tyr25Ter) in LCK (Tyrosine-protein kinase Lck) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
Y25* (p.Tyr25Ter) variant details
- p.Tyr25Ter
- rs747268826
- gnomAD 1-32274230-C-G
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.317
- CADD 10.50
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0474
- Literature evidence available