W13* (p.Trp13Ter) variant of LCK (Tyrosine-protein kinase Lck)
W13* (p.Trp13Ter) in LCK (Tyrosine-protein kinase Lck) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, experimental measurements, and structural context.
W13* (p.Trp13Ter) variant details
- p.Trp13Ter
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10028
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.249
- CADD 13.30
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.18