V44L (p.Val44Leu) variant of LCK (Tyrosine-protein kinase Lck)
V44L (p.Val44Leu) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V44L (p.Val44Leu) variant details
- p.Val44Leu
- cosmic curated COSV10028
- ExAC rs778290248
- TOPMed rs778290248
- gnomAD rs778290248
- Missense
- Variant Prioritization Score for Impact Estimate 0.258
- REVEL 0.06
- CADD 18.60
- PolyPhen-2 0.00
- SIFT 0.47
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.467