S7L (p.Ser7Leu) variant of LCK (Tyrosine-protein kinase Lck)
S7L (p.Ser7Leu) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S7L (p.Ser7Leu) variant details
- p.Ser7Leu
- gnomAD 1-32274349-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.38
- REVEL 0.12
- CADD 23.60
- PolyPhen-2 0.02
- SIFT 0.04
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.54
- Literature evidence available