S42C (p.Ser42Cys) variant of LCK (Tyrosine-protein kinase Lck)
S42C (p.Ser42Cys) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S42C (p.Ser42Cys) variant details
- p.Ser42Cys
- gnomAD 1-32274756-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.274
- REVEL 0.06
- CADD 22.40
- PolyPhen-2 0.00
- SIFT 0.14
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.129
- Literature evidence available