R45W (p.Arg45Trp) variant of LCK (Tyrosine-protein kinase Lck)
R45W (p.Arg45Trp) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R45W (p.Arg45Trp) variant details
- p.Arg45Trp
- rs139649211
- cosmic curated COSV60738
- ESP rs139649211
- ExAC rs139649211
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- REVEL 0.13
- CADD 23.20
- PolyPhen-2 0.43
- SIFT 0.07
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 9e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.357