R39Q (p.Arg39Gln) variant of LCK (Tyrosine-protein kinase Lck)
R39Q (p.Arg39Gln) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R39Q (p.Arg39Gln) variant details
- p.Arg39Gln
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10028
- Ensembl rs1640202238
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.277
- REVEL 0.11
- CADD 21.00
- PolyPhen-2 0.07
- SIFT 0.54
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.468