R39L (p.Arg39Leu) variant of LCK (Tyrosine-protein kinase Lck)
R39L (p.Arg39Leu) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R39L (p.Arg39Leu) variant details
- p.Arg39Leu
- gnomAD 1-32274747-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.16
- CADD 20.70
- PolyPhen-2 0.02
- SIFT 0.66
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.468
- Literature evidence available