P9L (p.Pro9Leu) variant of LCK (Tyrosine-protein kinase Lck)
P9L (p.Pro9Leu) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P9L (p.Pro9Leu) variant details
- p.Pro9Leu
- ExAC rs111771386
- TOPMed rs111771386
- gnomAD rs111771386
- Missense
- Variant Prioritization Score for Impact Estimate 0.191
- REVEL 0.12
- CADD 8.56
- PolyPhen-2 0.00
- SIFT 0.39
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.619