P57L (p.Pro57Leu) variant of LCK (Tyrosine-protein kinase Lck)
P57L (p.Pro57Leu) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P57L (p.Pro57Leu) variant details
- p.Pro57Leu
- NCI-TCGA Cosmic COSV6074
- cosmic curated COSV60742
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.36
- REVEL 0.09
- CADD 23.10
- PolyPhen-2 0.01
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.176