P56T (p.Pro56Thr) variant of LCK (Tyrosine-protein kinase Lck)
P56T (p.Pro56Thr) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
P56T (p.Pro56Thr) variant details
- p.Pro56Thr
- gnomAD 1-32274797-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.358
- REVEL 0.11
- CADD 20.10
- PolyPhen-2 0.01
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.138
- Literature evidence available