P56L (p.Pro56Leu) variant of LCK (Tyrosine-protein kinase Lck)
P56L (p.Pro56Leu) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P56L (p.Pro56Leu) variant details
- p.Pro56Leu
- rs761633690
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10028
- ExAC rs761633690
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.378
- REVEL 0.13
- CADD 22.20
- PolyPhen-2 0.01
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.138