P29S (p.Pro29Ser) variant of LCK (Tyrosine-protein kinase Lck)
P29S (p.Pro29Ser) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P29S (p.Pro29Ser) variant details
- p.Pro29Ser
- cosmic curated COSV10741
- NCI-TCGA TCGA novel
- TOPMed rs1640191298
- gnomAD rs1640191298
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.22
- REVEL 0.06
- CADD 23.00
- PolyPhen-2 0.21
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.227